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Since the beginning of the global spread of coronavirus infection, approaches to the treatment of patients have changed several times. The choice of therapeutic regimen depends on the severity of the course and clinical symptoms in a particular patient. All drugs should be prescribed by a doctor in accordance with current protocols and guidelines. The most effective medicines for coronavirus today are those that are prescribed on time and according to indications. Each of them has side effects, contraindications, features of the reception. However, many people self-medicate using unproven, ie dangerous, treatment regimens. In this article, we will look at drugs currently approved for the treatment of coronavirus infection COVID-19.
Classification of drugs for coronavirus The list of the best drugs for coronavirus should include drugs with proven effectiveness. According to the current methodological recommendations, the following groups of drugs are used:
* Antivirals. Assign from the moment the first symptoms appear in the absence of contraindications. It is pointless to take after 7-8 days of illness. * Artificial monoclonal antibodies (MAA) - can neutralize viral activity. * Anticovid plasma from recovered patient donors. * Immunosuppressants (glucocorticosteroids, interleukin receptor blockers) are drugs that suppress the excessive immune response that occurs during severe coronavirus infection?. * Anticoagulants are drugs that prevent blood clots.
TOP drugs for coronavirus
It is impossible to single out one best cure for coronavirus. The list of drugs used for covid (COVID-19) is quite large. Not every patient is shown one way or another. The treatment regimen is selected individually.
Pharmaceutical drugs, especially antiviral and immunosuppressive drugs, can cause severe side effects. Before using any medicine, you need to consult a doctor. At the same time, the patient himself should familiarize himself with possible contraindications, since they are not always voiced during the initial communication with a specialist.
1. Favipiravir
An antiviral drug artificially created in Japan, which was previously used to treat influenza and Ebola. Patients who take pills from the first days of the onset of symptoms recover faster. The medicine is prescribed both for treatment at home and in the hospital.
Contraindications: severe renal or hepatic insufficiency, pregnancy and lactation. It also cannot be used in the treatment of children.
2. Remdesivir
Injectable agent with antiviral activity for intravenous administration. Reduces the duration of illness by an average of 4 days. According to a clinical study, remdesivir reduces the risk of death by almost 62%?. But you can use it only in a hospital setting. Unreasonable use of remdesivir can lead to liver damage (an increase in liver enzymes will be seen in a biochemical blood test), the appearance of a skin rash, and a decrease in blood pressure (hypotension). There are also complications from the gastrointestinal tract, kidneys. Contraindications: patients under 18 years of age, pregnant and lactating women, the presence of severe liver and kidney diseases.
3. Umifenovir
An antiviral drug that is often used for mild coronavirus. However, its safety and efficacy have not been proven in clinical trials?. Assign from 6 years of age. Contraindications: Umifenovir is contraindicated during pregnancy, as its effect on the fetus and maternal health has not been studied.
4. Interferon-alpha
Another antiviral drug with a weak evidence base. In theory, the active substance should slow down the division of viral particles, relieve inflammation and stimulate one's own immunity. It is used in the form of drops in the nose in the complex treatment of mild forms of coronavirus or to prevent infection after contact with the patient. Contraindications: Pregnant patients can only use recombinant forms of interferon-alpha.
5. Baricitinib
Included in the group of anti-inflammatory drugs that are commonly used in the treatment of rheumatoid arthritis. Tablets should not be used as the main treatment for coronavirus infection. A large study conducted by the National Institute of Allergy and Infectious Diseases (NIAID) confirmed the effectiveness of baricitinib in covid. But it only works in tandem with antiviral drugs and anticoagulants. Assign in the case of mild and moderate course of the disease, including on an outpatient basis. Contraindications: the drug is contraindicated in patients with severe renal or hepatic insufficiency, including those caused by active viral hepatitis B / C. It is also not used in people with a high risk of blood clots or a history of thrombosis, with the addition of a secondary infection.
6. Netakimab
A drug from the group of human monoclonal antibodies for subcutaneous administration. Helps to improve oxygenation in the lungs during the development of pneumonia, softens the inflammatory response, accelerates recovery?. Contraindications: not everyone is prescribed the drug due to the high cost and individual contraindications. In a hospital setting, in the absence of netakimab, one of the following drugs with a similar effect can be used: olokizumab, levilimab, tocilizumab, sarilumab, canakinumab.